This drug was prescribed in the 1970’s as a venotonic agent for the treatment of circulatory disorders in women, notably heavy legs, venous insufficiency, and unsightly varicose veins. Rutin is a polyphenolic flavonoid acting as an antioxidant, which protects from oxidative stress and inflammation. It presents venoactive or phlebotonic properties and is also considered as a neuroprotective agent. This glycosylated flavonoid can be
Kalleone (known as kallidinogenase) is a hormone belonging to the kinin-kallikrein system which plays a key role in inflammation, vasodilation, smooth muscle contraction, cardioprotection, vascular permeability, blood pressure control and coagulation. This hormone was not frequently used in medical preparations and little information on kalleone is available.
Rustacol® is no longer used today, but rutin can be found in some herbal supplements and traditional natural medicines used as antioxidants and tonic agents.
Illustration of women heavy legs, requiring greater symptom relief, with the use of rustacol…