Duspatalin is a musculotropic antispasmodic drug active directly on smooth muscle within the gastrointestinal tract to relieve pain and unconfort. It is used for more than 50 years, favoring the relaxation of the muscles in and around the gut. It reduces the excessive contractility of smooth muscle cells. As such, it is a convenient product to treat stomach pain and cramps, persistent diarrhoea, and flatulence. The active principle is the anticholinergic molecule mebeverine hydrochloride which has a potent smooth muscle relaxant action.
This spasmolytic agent remains frequently used to day to treat gastroenterological disorders, notably irritable bowel syndrome (IBS). In addition to its musculotropic antispasmodic activity, it acts also as a calcium channel blocker and has regulatory effects on bowel function. “Duspatalin retard” is the oral form commonly used to day for the symptomatic treatment of abdominal pain and cramps, bowel disturbances and intestinal discomfort related to IBS.