The tablet drug Dactilase® was used to treat digestive troubles and digestive deficiencies. This complex eutectic preparation contained digestive enzymes (lipase, amylase, cellulase, protease) contained in a gastro-resistant envelope and an external layer composed of piperidolate hydrochloride (also known as Dactil). This later compound is an antimuscarinic small molecule acting as an inhibitor of glutathione S-transferase P1 (GSTP1). It contributes to inhibition of intestinal cramps induced by acetylcholine. Its anti-cholinergic action inhibited smooth muscle contraction. The drug has been used for the adjunctive management of functional gastrointestinal disorders characterized by pain, spasm, and hypermotility. Dactilase® was prescribed notably to patients with gastric or duodenal ulcer, gastritis, enteritis, cholelithiasis, cholecystitis or biliary dyskinesia. It was an efficient medicine (in the 1970s) to relieve abdominal pain and to reduce the sensation of intestinal heaviness (bloating, gas, sluggishness and digestive heaviness in general). Dactilase is no longer used today.
An illustration of the effect of the drug on intestinal transit, to restore digestive harmony.
