The drug Homeostan was used to treat psychosomatic diseases and dystonia. It was prescribed to instable, overactive children with acute emotional problems, and to adults with psychofunctional troubles. The drug was recommended to treat pathogenic emotion, notably for adults with psychosomatic disorders related to gynecology. Its active principle was the urea derivative N-acetyl-ethyl-2-cis-crotonyl-carbamide which is in fact the N-acetyl derivative of 2-ethylcrotonylurea. This latter product 2-(Z)-ethylcrotonylurea (or Ectylurea) is a tranquilizer used to treat anxiety, alcoholism and to calm mentally retarded patients. These two sedative products, largely prescribed in the 1960-70s, are no longer used today. But the ureide (N-acylurea) motif remains a common structure found in anticonvulsant products.
